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Synthetic biology innovation, building BioBricks with Bioline

By Bioline: The PCR Company 11 July 2013 No comments

The 6th International Meeting on Synthetic Biology (hashtag: #SB6Conf), the world’s foremost synthetic biology (SynBio) meeting, is currently running in London, organised by the BioBricks Foundation, a non-profit organization based in Cambridge, Massachusetts.

BioBricks Foundation SB6.0 Co-Chairs include Professor Paul Freemont and Professor Richard Kitney of Imperial College, who will lead a new £10 million innovation and knowledge centre, to be called SynbiCITE, aimed at providing a bridge between academia and industry and announced at the conference by David Willetts, Minister for Universities and Science.

Imperial College is home to the UK Centre for Synthetic Biology and Innovation a £9m investment aimed at propelling the synthetic biology field forward and promoting SynBio start-ups. International collaboration and networking are important aspects of the meeting, along with poster presentations and ‘lightning talks’ from world leaders in the field of SynBio research.

David Willets said:

"Synthetic biology has huge potential for our economy and society in so many areas, from life sciences to agriculture. But to realise this potential we need to ensure researchers and business work together. This new Innovation and Knowledge Centre will help advance scientific knowledge and turn cutting edge research into commercial success."

Professor Richard Kitney, co-academic of SynbiCITE added:

"Synthetic Biology could be the next ‘industrial revolution’ for the UK, where tiny devices manufactured from cells are used by us to improve many facets of our lives. From producing new, more sustainable fuels to developing devices that can monitor or improve our health, the applications in this field are limitless."

The exciting and emerging field of Synthetic Biology research combines the disciplines of engineering and molecular biology to design and build novel, biologically-based parts, devices, and sensors, as well as the re-engineering of existing, natural biological organisms. Synthetic Biology has the potential to deliver important new applications, from detecting the early onset of disease and improving existing industrial processes, food production, green fuels, and developing therapies to fight harmful bacterial infections or cancers.

Much of the future success of synthetic biology is incumbent upon the development of standardized SynBio components that can be combined in predictable and repeatable ways. The precise approach used when fabricating a BioBrick component depends on the fabrication method (PCR or direct synthesis) as well as the type of part being constructed (a standard part or protein coding sequence).

SyntheticBiology.org maintains a nice introduction to Synthetic Biology as well as a useful how-to guide on the subject of constructing novel BioBrick parts for submission to the Registry of Standard Biological Parts.

Bioline makes it easy to harness the power of new generation enzymes to create parts for BioBricks using PCR. We manufacture and supply a range of high-performance PCR and molecular biology cloning tools, enabling researchers to drive their synthetic biology projects forward. Some of our most popular, most frequently used products for leading synthetic biologists presenting at SB6.0 (1, 2) include the High-Fidelity Velocity DNA Polymerase, MyTaq HS DNA Polymerase for Colony-PCR, Competent Cells, Quick-Stick Ligase for TA Cloning, ISOLATE II Plasmid Mini Kits, and our acclaimed range of SensiMix™ and SensiFAST™ Real-Time PCR kits.

If you've been attending the #SB6Conf in London this week, let us know if your poster cites any Bioline reagents and your synthetic biology research work and achievements could be showcased in a forthcoming SynBio article on the Bioline blog. And if you’re one of the IGEMers attending the conference, don’t forget to check out our Gem of an offer for iGEM Teams!

One final note regarding the future of synthetic biology and the synthetic biologists of the future, you can keep up to date with all the latest news from the iGEM SynBio research teams around the world by following the international iGEM Teams Twitter list maintained by us @ThePCRCompany.

Citations

1. Giuraniuc CV, MacPherson M, Saka Y, et al. (2013). Gateway Vectors for Efficient Artificial Gene Assembly In Vitro and Expression in Yeast Saccharomyces cerevisiae. PLoS ONE 8(5): e64419. doi:10.1371/journal.pone.0064419

2. Ali H, Ries MI, Nijland JG, Lankhorst PP, Hankemeier T, et al. (2013). A Branched Biosynthetic Pathway Is Involved in Production of Roquefortine and Related Compounds in Penicillium chrysogenum. PLoS ONE 8(6): e65328. doi:10.1371/journal.pone.0065328

A Gem of an Offer for iGEM2013 Teams

By Bioline: The PCR Company 30 May 2013 No comments

Bioline - Proud Supporter of iGEM Participants

At Bioline we're proud to offer support to undergraduate student teams participating in the annual International Genetically Engineered Machine (iGEM) competition, an interdisciplinary project designed to advance the new and exciting research field of as synthetic biology (or ‘synbio’ for short) which combines life sciences and engineering.

There is a huge potential for synthetic biology to revolutionize our lives and already it is transforming the way in which living organisms and systems are designed to create new enzymes, fuels, food and medicines of the future. Many of our high-performance reagents for molecular biology are already used by researchers in their experiments, enabling them operate at the cutting edge of the emerging and rapidly developing 'SynBio' field.

iGEM2012 Recap

The iGEM2012 competition featured almost 200 teams from around the world. Two UK-based teams in Norwich and Cambridge were supported by Bioline and both teams went on to win gold medals in the European finals held in Amsterdam last October. The Cambridge team, one of three European finalists, was awarded "best experimental approach" and made it through to the world championships held at the Massachusetts Institute of Technology.

iGEM Synthetic Biology UK Teams Hangout at Google Campus, London. iGEM Synthetic Biology UK Teams Hangout at Google Campus, London. Photo courtesy of Richard Kelwick

The Norwich Research Park and University of East Anglia (NRP UEA) iGEM Team

NRP UEA iGEM 2012 Team. NRP UEA iGEM 2012 Team. Photo courtesy of Richard Kelwick

Home to some 2,700 scientists, NRP is one of Europe’s largest single-site concentrations of researchers in Environmental and Biological Sciences. This was the second iGEM team from Norwich to participate in the competition, and were mentored by Dr Richard Kelwick.

Team NRP UEA set out to develop a new system of innovative bacteria to help solve problems throughout the world. They focussed on the role of nitric oxide (NO) and aimed to produce a biological system that can sense nitric oxide levels within an environment. Once completed, the biological system could have potential uses in many areas, including developments for future cancer therapies and for detection of NO levels in the environment; such as soil.

University of Cambridge iGEM2012 Team

The University of Cambridge has a strong history in the iGEM competition, having entered annually since 2005, and is advised by the Haseloff, Ajioka and Micklem labs. The Cambridge iGEM team set out to create new standards for characterisation, validation and application of biosensors. The protocols were modular in design, allowing any biosensor built to this standard to be measured with low-cost prototype instrumentation. Existing and novel biosensors were designed to be adapted to use light as an output to facilitate an interface with microcontroller electronics.

The University of Leicester iGEM2012 Team

University of Leicester iGEM Team with their Bioline Account Manager University of Leicester iGEM Team with their Bioline Account Manager

With support from the Badge lab at the Genetics Department, the Leicester iGEM team set out to solve an important environmental problem - namely to reduce the waste going to landfill by engineering a bacterium to degrade polystyrene. Some bacteria form biofilms on polystyrene, indicating that polystyrene may be degraded. Identification of the degradation genes/pathway(s) responsible, could be coupled to synthesis of useful products in the future e.g. biofoam.

Congratulations and good luck for iGEM2013!

We were extremely impressed by the tremendous efforts of all iGEM teams in getting so far in the regional and world finals. We (vicariously!) enjoyed the buzz of the competition via the tweets and blog updates issued by the teams.

To show our commitment to helping develop the bio-scientists of the future, we have expanded our support to all iGEM teams in the United Kingdom by offering up to 50% off our already highly-competitive list prices. And, of course, all Bioline products are backed by our friendly and helpful UK based technical support staff, should you need it!

To request full details of our Gem of an iGEM offer pricing plan, please contact your local Bioline account manager using our rep finder tool. Then, why not let your fellow iGem researchers know too by clicking the lovely button below.

Tweet ThisWe wish all iGEM2013 entrants every success in this year's competition!

A GEM of an offer for iGEM Researchers – Up to 35% OFF Bioline Reagents!

By Bioline: The PCR Company 18 July 2012 No comments

Bioline - The PCR Company Bioline: The PCR Company

Bioline: The PCR Company was founded in 1992 in London – the dynamic city that will soon be hosting a major international sporting event in Stratford – to provide high-quality and cost-effective reagents for molecular biology, with the core aim of simplifying, accelerating and improving research in the field of life sciences.

The thinking and principles behind the founding of Bioline are similar to those of the interdisciplinary International Genetically Engineered Machine (iGEM) competition that was established in 2003, with the aim of encouraging and developing undergraduate scientific research.

To celebrate our 20th anniversary of services to life science, bolster the support we provide to young molecular biologists and as part of our commitment to helping nurture the scientists of the future, we are pleased to announce an exclusive special offer for all UK-based iGEM researchers – up to 35% off our already highly-competitive list prices!

Many of our reagents are available as free samples, so you’re welcome to try before you buy and all Bioline products are backed with full technical support from our UK-based support staff.

If you’re part of a UK-based iGEM team and need high-quality reagents at the best possible prices to bring your iGEM project to fruition, get full details of our exclusive iGEM researcher pricing plan by contacting your local Bioline account manager using our Rep Finder tool.  Alternatively, call us direct on 020 8452 2822.

It just remains for us to wish all iGEM researchers the greatest of success in this year’s competition!

Terms & Conditions

Offer only available to UK-based researchers participating in the 2012 iGEM competition. This special offer cannot be used in conjunction with any other special offer or discount. Offer valid until 30.09.2012.

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